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Akademie věd České republiky - Požadavky

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Požadavky
Výběrová řízení - Akademie věd České republikyLaboratory of Pancreatic Islet Research,Institute of Physiology,Czech Academy of Sciences,Prague,Czech Republic is looking for a new team member: Postdoctoral position in XXX Laboratory of Pancreatic Islet Research Head (email): XXXXX XXXXXXX (lydie.plecita@fgu.cas.cz) Laboratory website: https:// www.fgu.cas.cz/en/departments/laboratory-of-pancreatic-islet-research Postdoctoral project: Our newly established laboratory investigates the physiology and pathophysiology of pancreatic beta cells.Beta cells XXX XXX guardians of glucose homeostasis in XXX XXXX,and their deficiency and impaired function trigger the development of diabetes.We focus on the role of redox signalling during glucose stimulation in XXXX cells because of XXX vulnerability of redox homeostasis.Altered redox status can impair insulin secretion,while in XXX XXXX term it can trigger cellular stress.In addition,altered redox signalling has significant effects on other endocrine cells in XXX pancreatic islets (mainly alpha/glucagon secreting and delta/somatostatin secreting cells).XXX XXX of this project is to investigate the effects of altered redox signalling on paracrine signalling between beta and alpha cells.The project focuses mainly on the role of paracrine GLP1 and glucagon signalling.A unique mouse model with altered redox status in XXXX cells and pancreatic slices/isolated islets of Langerhans/cells will be used for the study.Novel experimental strategies in combination with confocal microscopy will be used <.> Candidate’s profile (requirements): We are looking for talented and motivated biological problem-solving graduates with a background in biological and biomedical sciences.Experience with cell culture,mouse/rat models,molecular biology,biochemistry and fluorescence microscopy is an advantage <.> We offer: Highly interdisciplinary work in a creative academic environment.Everyone can contribute ideas to move the project forward <.> Fixed-ter...

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